Loss of penicillin tolerance by inactivating the carbon catabolite repression determinant CcpA in Streptococcus gordonii | Zendy

Alain Bizzini | Zendy; José M. Entenza | Zendy; Philippe Moreillon | Zendy

Open Access

Loss of penicillin tolerance by inactivating the carbon catabolite repression determinant CcpA in Streptococcus gordonii

Author(s) -

Alain Bizzini,

José M. Entenza,

Philippe Moreillon

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm021

Subject(s) - ccpa , catabolite repression , streptococcus gordonii , microbiology and biotechnology , operon , penicillin , biology , mutant , fed batch culture , genetics , streptococcaceae , gene , biochemistry , fermentation , antibiotics

Antibiotic tolerance is a phenomenon allowing bacteria to withstand drug-induced killing. Here, we studied a penicillin-tolerant mutant of Streptococcus gordonii (Tol1), which was shown to be deregulated in the expression of the arginine deiminase operon (arc). arc was not directly responsible for tolerance, but is controlled by the global regulator CcpA. Therefore, we sought whether CcpA might be implicated in tolerance.

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