Inhibition of HIV-1 replication in macrophages by a heterodinucleotide of lamivudine and tenofovir | Zendy

Luigia Rossi | Zendy; Palmarisa Franchetti | Zendy; Francesca Pierigè | Zendy; Loredana Cappellacci | Zendy; Sonja Serafini | Zendy; E Balestra | Zendy; Carlo Federico Perno | Zendy; Mario Grifantini | Zendy; R Caliò | Zendy; Mauro Magnani | Zendy

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Inhibition of HIV-1 replication in macrophages by a heterodinucleotide of lamivudine and tenofovir

Author(s) -

Luigia Rossi,

Palmarisa Franchetti,

Francesca Pierigè,

Loredana Cappellacci,

Sonja Serafini,

E Balestra,

Carlo Federico Perno,

Mario Grifantini,

R Caliò,

Mauro Magnani

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkm011

Subject(s) - lamivudine , phagocytosis , in vivo , macrophage , in vitro , viral replication , virus , pharmacokinetics , biology , pharmacology , virology , chemistry , microbiology and biotechnology , biochemistry , hepatitis b virus

(i) To generate a new heterodinucleotide (3TCpPMPA) comprising the drugs lamivudine and tenofovir which have been shown to act synergistically and (ii) to protect macrophages from 'de novo' HIV-1-infection through its administration.

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