Compounds with antibacterial activity that enhance DNA cleavage by bacterial DNA topoisomerase I | Zendy

Bokun Cheng | Zendy; IFen Liu | Zendy; YukChing TseDinh | Zendy

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Compounds with antibacterial activity that enhance DNA cleavage by bacterial DNA topoisomerase I

Author(s) -

Bokun Cheng,

IFen Liu,

YukChing TseDinh

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl556

Subject(s) - topoisomerase , dna , cleavage (geology) , dna supercoil , antibacterial activity , covalent bond , chemistry , biochemistry , biology , bacteria , dna replication , genetics , paleontology , organic chemistry , fracture (geology)

DNA topoisomerases utilize a covalent complex formed after DNA cleavage as an intermediate in the interconversion of topological forms via DNA cleavage and religation. Many anticancer and antibacterial therapeutic agents are effective because they stabilize or increase the level of the covalent topoisomerase-DNA complex formed by type IIA or type IB topoisomerases. Our goal is to identify small molecules that can enhance DNA cleavage by type IA DNA topoisomerase. Compounds that act in this mechanism against type IA topoisomerase have not been identified previously and could be leads for development of a new class of antibacterial agents.

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