Transfer of plasmid and chromosomal glycopeptide resistance determinants occurs more readily in the digestive tract of mice than in vitro and exconjugants can persist stably in vivo in the absence of glycopeptide selection | Zendy

Kristin Hegstad | Zendy; Denis D.G. Mater | Zendy; M.J. Flores | Zendy; Pål J. Johnsen | Zendy; Tore Midtvedt | Zendy; Gérard Corthier | Zendy; Arnfinn Sundsfjord | Zendy

Open Access

Transfer of plasmid and chromosomal glycopeptide resistance determinants occurs more readily in the digestive tract of mice than in vitro and exconjugants can persist stably in vivo in the absence of glycopeptide selection

Author(s) -

Kristin Hegstad,

Denis D.G. Mater,

M.J. Flores,

Pål J. Johnsen,

Tore Midtvedt,

Gérard Corthier,

Arnfinn Sundsfjord

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl530

Subject(s) - glycopeptide , in vivo , biology , plasmid , enterococcus faecium , microbiology and biotechnology , in vitro , transferability , genetics , antibiotics , gene , statistics , mathematics , logit

The transferability of vanA and vanB glycopeptide resistance determinants with a defined plasmid (n = 9) or chromosomal (n = 4) location between Enterococcus faecium strains of human and animal origins was compared using filter mating (in vitro) and germ-free mice (in vivo) as experimental models. Moreover, the stability of exconjugants in vivo in the absence of antibiotic selection was examined.

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