Biofilm formation by fluconazole-resistant Candida albicans strains is inhibited by fluconazole | Zendy

Igor Bruzual | Zendy; Perry J. Riggle | Zendy; Susan Hadley | Zendy; Carol A. Kumamoto | Zendy

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Biofilm formation by fluconazole-resistant Candida albicans strains is inhibited by fluconazole

Author(s) -

Igor Bruzual,

Perry J. Riggle,

Susan Hadley,

Carol A. Kumamoto

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl521

Subject(s) - fluconazole , biofilm , microbiology and biotechnology , candida albicans , corpus albicans , drug resistance , azole , antimicrobial , biology , antifungal , bacteria , genetics

The fungal pathogen Candida albicans forms biofilms on implanted medical devices, resulting in infections with high mortality. Fully developed biofilms, which are adherent communities of microorganisms, characteristically exhibit high resistance to antimicrobial drugs, making treatment of device-associated infection problematic. The aim of this study was to determine the effect of the addition of the azole antifungal fluconazole on the initiation of biofilm formation by both drug-susceptible and drug-resistant C. albicans strains.

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