A novel ex vivo skin model to study the susceptibility of the dermatophyte Trichophyton rubrum to photodynamic treatment in different growth phases | Zendy

Threes G. M. Smijs | Zendy; Joke A. Bouwstra | Zendy; Hans J. Schuitmaker | Zendy; M. Talebi | Zendy; Stan Pavel | Zendy

Open Access

A novel ex vivo skin model to study the susceptibility of the dermatophyte Trichophyton rubrum to photodynamic treatment in different growth phases

Author(s) -

Threes G. M. Smijs,

Joke A. Bouwstra,

Hans J. Schuitmaker,

M. Talebi,

Stan Pavel

Publication year - 2007

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl490

Subject(s) - trichophyton rubrum , dermatophyte , photodynamic therapy , ex vivo , microbiology and biotechnology , in vivo , trichophyton , stratum corneum , incubation , incubation period , biology , chemistry , biochemistry , antifungal , genetics , organic chemistry

Dermatophytes are fungi that can cause infections of skin, hair and nails because of their ability to feed on keratin. Superficial mycoses are among the most prevalent infectious diseases worldwide. Two important restrictions of current therapeutic options are the recurrence of the infection and prolonged treatment. This is especially true for infections caused by Trichophyton rubrum, a widely distributed dermatophyte. The application of photosensitizers for treatment of fungal infections is, within the field of photodynamic treatment (PDT), relatively new. Recently, we demonstrated that the porphyrins 5,10,15-tris(4-methylpyridinium)-20-phenyl-[21H,23H]-porphine trichloride (Sylsens B) and deuteroporphyrin monomethylester (DP mme) were excellent photosensitizers towards T. rubrum when using red light.

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