Ertapenem in critically ill patients with early-onset ventilator-associated pneumonia: pharmacokinetics with special consideration of free-drug concentration | Zendy

Olaf Burkhardt | Zendy; Vipul Kumar | Zendy; D. Katterwe | Zendy; J. MajcherPeszynska | Zendy; Bernd Drewelow | Zendy; Hartmut Derendorf | Zendy; Tobias Welte | Zendy

Open Access

Ertapenem in critically ill patients with early-onset ventilator-associated pneumonia: pharmacokinetics with special consideration of free-drug concentration

Author(s) -

Olaf Burkhardt,

Vipul Kumar,

D. Katterwe,

J. MajcherPeszynska,

Bernd Drewelow,

Hartmut Derendorf,

Tobias Welte

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl485

Subject(s) - ertapenem , pharmacokinetics , medicine , population , nonmem , therapeutic drug monitoring , cmax , pneumonia , pharmacology , antibiotics , antibacterial agent , ventilator associated pneumonia , meropenem , microbiology and biotechnology , biology , antibiotic resistance , environmental health

Most information about pharmacokinetics of antimicrobial agents is obtained from studies in healthy volunteers. However, antibiotics are therapeutically used in infected patients with very different pharmacokinetic properties compared with healthy individuals.

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