Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae | Zendy

Ronald Anderson | Zendy; Helen C. Steel | Zendy; Riana Cockeran | Zendy; Anthony M. Smith | Zendy; Anne von Gottberg | Zendy; Linda de Gouveia | Zendy; Adrian Brink | Zendy; Keith P. Klugman | Zendy; Timothy J. Mitchell | Zendy; Charles Feldman | Zendy

Open Access

Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae

Author(s) -

Ronald Anderson,

Helen C. Steel,

Riana Cockeran,

Anthony M. Smith,

Anne von Gottberg,

Linda de Gouveia,

Adrian Brink,

Keith P. Klugman,

Timothy J. Mitchell,

Charles Feldman

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl479

Subject(s) - pneumolysin , microbiology and biotechnology , streptococcus pneumoniae , clarithromycin , ceftriaxone , macrolide antibiotics , antibiotics , biology , virology , erythromycin

To investigate the effects of clarithromycin (0.01-0.5 mg/L) alone or in combination with ceftriaxone (0.1 and 0.25 mg/L) on pneumolysin production by both macrolide-susceptible and -resistant [2 erm(B) positive and 2 mef(A) positive] strains of Streptococcus pneumoniae.

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