Small-colony variants: a novel mechanism for triclosan resistance in methicillin-resistant Staphylococcus aureus | Zendy

Paul F. Seaman | Zendy; Dietmar Ochs | Zendy; Martin J. Day | Zendy

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Small-colony variants: a novel mechanism for triclosan resistance in methicillin-resistant Staphylococcus aureus

Author(s) -

Paul F. Seaman,

Dietmar Ochs,

Martin J. Day

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl450

Subject(s) - triclosan , staphylococcus aureus , microbiology and biotechnology , antimicrobial , methicillin resistant staphylococcus aureus , biology , antibiotic resistance , antibiotics , drug resistance , gentamicin , medicine , bacteria , genetics , pathology

A little-understood mode of antimicrobial resistance in Staphylococcus aureus is the evolution of a sub-population of small-colony variants (SCVs). SCVs are a cause of persistent and recurring infections refractory to antimicrobial chemotherapy. Following the inadvertent isolation of suspected SCVs growing in the presence of triclosan we set out to evaluate the formation of these colonial mutants and assess their antimicrobial susceptibility.

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