Open AccessEvaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth
Author(s) -
Mary C. Long,
Paula W. Allan,
M.Z. LUO,
M.-C. Liu,
Alan C. Sartorelli,
William B. Parker
Publication year - 2006
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkl448
Subject(s) - adenosine , mycobacterium tuberculosis , tuberculosis , adenosine kinase , microbiology and biotechnology , pharmacology , chemistry , virology , medicine , biology , biochemistry , adenosine deaminase , pathology
Analyse a series of halogenated 3-deaza-adenosine analogues for efficacy against Mycobacterium tuberculosis H37Ra and determine if adenosine (Ado) kinase plays a role in the mechanism of action of these compounds.
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