Minocycline delays but does not attenuate the course of experimental autoimmune encephalomyelitis in Streptococcus pneumoniae-infected mice | Zendy

Ina Herrmann | Zendy; Marco Kellert | Zendy; Annette Spreer | Zendy; J. Gerber | Zendy; Helmut Eiffert | Zendy; Marco Prinz | Zendy; Roland Nau | Zendy

Open Access

Minocycline delays but does not attenuate the course of experimental autoimmune encephalomyelitis in Streptococcus pneumoniae-infected mice

Author(s) -

Ina Herrmann,

Marco Kellert,

Annette Spreer,

J. Gerber,

Helmut Eiffert,

Marco Prinz,

Roland Nau

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl446

Subject(s) - minocycline , experimental autoimmune encephalomyelitis , streptococcus pneumoniae , ceftriaxone , medicine , immunology , proinflammatory cytokine , antibiotics , pharmacology , multiple sclerosis , microbiology and biotechnology , biology , inflammation

Experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), can be aggravated by a mild Streptococcus pneumoniae infection. This study was performed to assess whether treatment with antibiotics inhibiting bacterial protein synthesis reduces the detrimental effect of infection on the course of EAE.

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