Open AccessAntisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli
Author(s) -
Lucas D. Tilley,
Brett L. Mellbye,
Susan Puckett,
Patrick L. Iversen,
Bruce L. Geller
Publication year - 2006
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkl444
Subject(s) - morpholino , peptide , escherichia coli , conjugate , chemistry , cell penetrating peptide , microbiology and biotechnology , biology , biochemistry , gene , gene knockdown , mathematical analysis , mathematics
Phosphorodiamidate morpholino oligomers (PMOs) are DNA analogues that inhibit translation by an antisense mechanism. Membrane-penetrating peptides attached to PMOs increase PMO efficacy by enhancing penetration through bacterial membranes. The objectives of these experiments are to demonstrate gene-specific efficacy and establish a dose-response relationship of a peptide-PMO conjugate.