Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli | Zendy

Lucas D. Tilley | Zendy; Brett L. Mellbye | Zendy; Susan Puckett | Zendy; Patrick L. Iversen | Zendy; Bruce L. Geller | Zendy

Open Access

Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli

Author(s) -

Lucas D. Tilley,

Brett L. Mellbye,

Susan Puckett,

Patrick L. Iversen,

Bruce L. Geller

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl444

Subject(s) - morpholino , peptide , escherichia coli , conjugate , chemistry , cell penetrating peptide , microbiology and biotechnology , biology , biochemistry , gene , gene knockdown , mathematical analysis , mathematics

Phosphorodiamidate morpholino oligomers (PMOs) are DNA analogues that inhibit translation by an antisense mechanism. Membrane-penetrating peptides attached to PMOs increase PMO efficacy by enhancing penetration through bacterial membranes. The objectives of these experiments are to demonstrate gene-specific efficacy and establish a dose-response relationship of a peptide-PMO conjugate.

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