Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF) | Zendy

Jürgen A. Bohnert | Zendy; Sabine Schuster | Zendy; Eva Fähnrich | Zendy; Rainer Trittler | Zendy; Winfried V. Kern | Zendy

Open Access

Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF)

Author(s) -

Jürgen A. Bohnert,

Sabine Schuster,

Eva Fähnrich,

Rainer Trittler,

Winfried V. Kern

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl426

Subject(s) - efflux , biology , ethidium bromide , escherichia coli , mutant , microbiology and biotechnology , multiple drug resistance , novobiocin , point mutation , wild type , tetracycline , 23s ribosomal rna , drug resistance , antibiotics , gene , biochemistry , dna , ribosome , rna

YhiV (MdtF) is an resistance nodulation division (RND) type efflux pump in Escherichia coli with significant homology to AcrB but usually expressed at a low level in clinical isolates. When overexpressed the pump confers decreased susceptibility to a variety of substances including erythromycin and ethidium bromide (EtBr). We characterized two mutants of E. coli E12 (DeltaacrB DeltaacrF) overexpressing yhiV that showed surprising differences in their spectrum of multidrug resistance (MDR).

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