Comparative in vivo activity of BAL4815, the active component of the prodrug BAL8557, in a neutropenic murine model of disseminated Aspergillus flavus | Zendy

Peter Warn | Zendy; Joanne Sharp | Zendy; Juan Alejandro Neira Mosquera | Zendy; Jochen Spickermann | Zendy; Anne SchmittHoffmann | Zendy; M. Heep | Zendy; David W. Denning | Zendy

Open Access

Comparative in vivo activity of BAL4815, the active component of the prodrug BAL8557, in a neutropenic murine model of disseminated Aspergillus flavus

Author(s) -

Peter Warn,

Joanne Sharp,

Juan Alejandro Neira Mosquera,

Jochen Spickermann,

Anne SchmittHoffmann,

M. Heep,

David W. Denning

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl396

Subject(s) - aspergillus flavus , in vivo , prodrug , microbiology and biotechnology , antibiotics , pharmacology , medicine , biology

BAL8557 (WSA) is the water-soluble prodrug of the triazole BAL4815 with in vitro anti-Aspergillus activity. We compared the activity of oral BAL8557 with oral itraconazole, oral voriconazole and intravenous caspofungin in a temporarily neutropenic murine model of disseminated Aspergillus flavus.

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