Bactericidal activity and target preference of a piperazinyl-cross-linked ciprofloxacin dimer with Staphylococcus aureus and Escherichia coli | Zendy

Xilin Zhao | Zendy; Brian Quinn | Zendy; Robert J. Kerns | Zendy; Karl Drlica | Zendy

Open Access

Bactericidal activity and target preference of a piperazinyl-cross-linked ciprofloxacin dimer with Staphylococcus aureus and Escherichia coli

Author(s) -

Xilin Zhao,

Brian Quinn,

Robert J. Kerns,

Karl Drlica

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl388

Subject(s) - staphylococcus aureus , microbiology and biotechnology , ciprofloxacin , escherichia coli , streptococcus pneumoniae , mycobacterium smegmatis , biology , bacteria , chemistry , medicine , antibiotics , biochemistry , mycobacterium tuberculosis , gene , genetics , tuberculosis , pathology

Previous work showed that piperazinyl-cross-linked ciprofloxacin dimer exhibits good bacteriostatic activity with Streptococcus pneumoniae and Staphylococcus aureus; lethal activity was not measured. Subsequently, the dimer failed to kill Mycobacterium smegmatis but blocked growth. Whether the compound is lethal with non-mycobacterial species is not known.

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