Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to daptomycin and vancomycin in an in vitro dynamic model | Zendy

Alexander A. Firsov | Zendy; Maria V. Smirnova | Zendy; Irene Yu Lubenko | Zendy; Sergey N. Vostrov | Zendy; Yury A. Portnoy | Zendy; Stephen H. Zinner | Zendy

Open Access

Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to daptomycin and vancomycin in an in vitro dynamic model

Author(s) -

Alexander A. Firsov,

Maria V. Smirnova,

Irene Yu Lubenko,

Sergey N. Vostrov,

Yury A. Portnoy,

Stephen H. Zinner

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl387

Subject(s) - daptomycin , staphylococcus aureus , vancomycin , antibiotics , pharmacodynamics , microbiology and biotechnology , mutant , in vitro , biology , medicine , pharmacology , bacteria , pharmacokinetics , genetics , gene

To extend the mutant selection window (MSW) hypothesis to include antibiotics in addition to fluoroquinolones, the pharmacodynamics of daptomycin (DAP) and vancomycin (VAN) and their ability to prevent the selection of resistant Staphylococcus aureus were studied in an in vitro model that simulates antibiotic concentrations below the MIC, between the MIC and the mutant prevention concentration (MPC), and above the MPC.

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