Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation | Zendy

Anja Schumacher | Zendy; Rainer Trittler | Zendy; Jürgen A. Bohnert | Zendy; Klaus Kümmerer | Zendy; JeanMarie Pagès | Zendy; Winfried V. Kern | Zendy

Open Access

Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation

Author(s) -

Anja Schumacher,

Rainer Trittler,

Jürgen A. Bohnert,

Klaus Kümmerer,

JeanMarie Pagès,

Winfried V. Kern

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl380

Subject(s) - efflux , citrobacter freundii , enterobacter aerogenes , linezolid , microbiology and biotechnology , norfloxacin , intracellular , chemistry , escherichia coli , staphylococcus aureus , enterobacteriaceae , biology , biochemistry , bacteria , antibiotics , ciprofloxacin , vancomycin , genetics , gene

The oxazolidinone class of antibiotics such as linezolid have a narrow spectrum of activity that targets Gram-positive bacteria. We hypothesized that the poor activity of linezolid in Gram-negative bacteria is in part caused by relatively low intracellular concentration due to efflux.

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