Mutations conferring zanamivir resistance in human influenza virus N2 neuraminidases compromise virus fitness and are not stably maintained in vitro | Zendy

Thomas Zürcher | Zendy

Open Access

Mutations conferring zanamivir resistance in human influenza virus N2 neuraminidases compromise virus fitness and are not stably maintained in vitro

Author(s) -

Thomas Zürcher

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl321

Subject(s) - zanamivir , neuraminidase , biology , virology , virus , oseltamivir , neuraminidase inhibitor , resistance mutation , influenza a virus , viral replication , microbiology and biotechnology , recombinant dna , mutation , genetics , gene , reverse transcriptase , polymerase chain reaction , medicine , disease , pathology , covid-19 , infectious disease (medical specialty)

Viruses resistant to zanamivir have been generated in vitro, but no resistant virus has yet been isolated from a zanamivir-treated immunocompetent patient. In contrast most resistant viruses isolated from oseltamivir-treated patients correspond to those selected in vitro. However, despite mutations being in conserved residues in the neuraminidase (NA) they do not confer resistance in all NA subtypes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research