Mutators among CTX-M -lactamase-producing Escherichia coli and risk for the emergence of fosfomycin resistance | Zendy

M.J. Ellington | Zendy

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Mutators among CTX-M -lactamase-producing Escherichia coli and risk for the emergence of fosfomycin resistance

Author(s) -

M.J. Ellington

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl315

Subject(s) - fosfomycin , microbiology and biotechnology , nitrofurantoin , rifampicin , escherichia coli , biology , nalidixic acid , antibiotics , antibiotic resistance , genetics , gene

Fosfomycin is a possible oral treatment for lower urinary tract infections caused by Escherichia coli with CTX-M extended-spectrum beta-lactamases but is vulnerable to mutational resistance. Hypermutability among natural E. coli populations might facilitate the emergence of resistance to fosfomycin. We therefore examined the prevalence of mutators amongst urinary isolates of E. coli producing CTX-M beta-lactamases.

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