In vitro activity of a new antibacterial rhodanine derivative against Staphylococcus epidermidis biofilms | Zendy

Maxime Gualtiéri | Zendy

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In vitro activity of a new antibacterial rhodanine derivative against Staphylococcus epidermidis biofilms

Author(s) -

Maxime Gualtiéri

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl314

Subject(s) - staphylococcus epidermidis , biofilm , microbiology and biotechnology , antibiotics , rifampicin , staphylococcus aureus , bacteria , chemistry , in vitro , biology , biochemistry , genetics

Staphylococcus epidermidis biofilms form at the surface of implants and prostheses and are responsible for the failure of many antibiotic therapies. Only a few antibiotics are relatively active against biofilms, and rifampicin, a transcription inhibitor, is among the most effective molecules for treating biofilm-related infections. Having recently selected a new potential transcription inhibitor, we attempted to evaluate its efficacy against S. epidermidis biofilms.

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