Penetration of ertapenem into skeletal muscle and subcutaneous adipose tissue in healthy volunteers measured by in vivo microdialysis | Zendy

Olaf Burkhardt | Zendy

Open Access

Penetration of ertapenem into skeletal muscle and subcutaneous adipose tissue in healthy volunteers measured by in vivo microdialysis

Author(s) -

Olaf Burkhardt

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl284

Subject(s) - microdialysis , ertapenem , in vivo , subcutaneous tissue , adipose tissue , penetration (warfare) , medicine , soft tissue , skeletal muscle , muscle tissue , biomedical engineering , pathology , anatomy , antibiotics , biology , microbiology and biotechnology , meropenem , antibiotic resistance , operations research , engineering

Ertapenem is FDA approved for the treatment of skin and skin-structure infections (SSSI), but its in vivo penetration into the interstitial space of soft tissues is unknown. The present microdialysis study was conducted to measure free, protein-unbound ertapenem concentrations in muscle and subcutaneous tissue.

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