Reversing methicillin resistance in MRSA using a bacterial transforming agent | Zendy

Brighid Carey | Zendy

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Reversing methicillin resistance in MRSA using a bacterial transforming agent

Author(s) -

Brighid Carey

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl245

Subject(s) - antimicrobial , methicillin resistant staphylococcus aureus , microbiology and biotechnology , staphylococcus aureus , antibiotics , etest , antibiotic resistance , minimum inhibitory concentration , medicine , staphylococcal infections , drug resistance , biology , bacteria , genetics

Antimicrobial resistance in staphylococci remains a significant problem in the clinical management of infections. New therapeutic entities are required for the prophylaxis and treatment of staphylococcal infection including those caused by methicillin-resistant Staphylococcus aureus (MRSA). Potential candidates include bacterial transforming agents (BTAs), compounds that can potentiate the activity of cell-wall-active antimicrobials by hypersensitizing the bacterial cell wall to the bactericidal effects of these drugs. BTAs have been found to inhibit MRSA in vitro when administered in combination with established antibiotics.

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