Caspofungin activity against clinical isolates of azole cross-resistant Candida glabrata overexpressing efflux pump genes | Zendy

Brunella Posteraro | Zendy

Open Access

Caspofungin activity against clinical isolates of azole cross-resistant Candida glabrata overexpressing efflux pump genes

Author(s) -

Brunella Posteraro

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl237

Subject(s) - caspofungin , fluconazole , azole , candida glabrata , itraconazole , voriconazole , microbiology and biotechnology , biology , efflux , echinocandin , ketoconazole , pharmacology , antifungal , biochemistry

Several studies have documented the potent in vitro activity of caspofungin against Candida spp. This is of special concern for Candida glabrata infections that are often resistant to many azole antifungal agents and, consequently, difficult to treat. The aim of the present study was to expand the data on the in vitro activity of caspofungin against azole-resistant isolates of C. glabrata.

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