Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines | Zendy

K. N. Agwuh | Zendy

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Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines

Author(s) -

K. N. Agwuh

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl224

Subject(s) - minocycline , pharmacokinetics , pharmacodynamics , doxycycline , oxytetracycline , tigecycline , pharmacology , tetracycline , medicine , antibiotics , antibacterial agent , microbiology and biotechnology , biology

The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups. Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, demeclocycline, lymecycline, methacycline and rolitetracycline is characterized by poor absorption after food. Group 2, represented by doxycycline and minocycline, is more reliably absorbed orally, while group 3, represented by the glycylcycline tigecycline, is injectable only, with an improved antibacterial spectrum compared with the tetracyclines. Though incompletely understood, the pharmacodynamic properties of the tetracyclines and glycylcyclines are summarized.

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