Multidrug resistance pump AcrAB-TolC is required for high-level, Tet(A)-mediated tetracycline resistance in Escherichia coli | Zendy

Ricardo Cristóbal | Zendy; P Vincent | Zendy; Raúl A. Salomón | Zendy

Open Access

Multidrug resistance pump AcrAB-TolC is required for high-level, Tet(A)-mediated tetracycline resistance in Escherichia coli

Author(s) -

Ricardo Cristóbal,

P Vincent,

Raúl A. Salomón

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl172

Subject(s) - tn10 , tetracycline , efflux , escherichia coli , biology , mutant , microbiology and biotechnology , plasmid , tetr , mutation , multiple drug resistance , enterobacteriaceae , drug resistance , genetics , antibiotics , repressor , gene , gene expression

Starting from the observation that Escherichia coli tolC mutations severely reduced the high-level resistance to tetracycline afforded by Tn10- and plasmid-encoded Tet(A) pumps, we studied the mechanism of this susceptibility.

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