Pharmacodynamic activity of garenoxacin against ciprofloxacin-resistant Streptococcus pneumoniae | Zendy

George G. Zhanel | Zendy

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Pharmacodynamic activity of garenoxacin against ciprofloxacin-resistant Streptococcus pneumoniae

Author(s) -

George G. Zhanel

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl159

Subject(s) - ciprofloxacin , microbiology and biotechnology , streptococcus pneumoniae , efflux , pharmacodynamics , antibacterial agent , chemistry , quinolone , levofloxacin , antibiotics , pharmacology , biology , pharmacokinetics , biochemistry

The pharmacodynamic parameter that best correlates with bacteriological eradication for fluoroquinolones is the free (f) area under the 24 h serum concentration curve (AUC24) to MIC (fAUC24/MIC) ratio. This study assessed garenoxacin fAUC24/MIC against ciprofloxacin-resistant Streptococcus pneumoniae using an in vitro pharmacodynamic model.

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