In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum | Zendy

Bruno Pradines | Zendy

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In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum

Author(s) -

Bruno Pradines

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl117

Subject(s) - amodiaquine , plasmodium falciparum , atovaquone , artemether , quinine , chloroquine , pyrimethamine , pharmacology , in vitro , cross resistance , malaria , artesunate , proguanil , chemistry , microbiology and biotechnology , biology , artemisinin , biochemistry , immunology

The in vitro activities of FR160, a synthetic catecholate siderophore, and two iron-binding agents, desferrioxamine and doxycycline, were evaluated against Plasmodium falciparum isolates. Correlations between these compounds and standard antimalarial drugs (chloroquine, quinine, amodiaquine, pyronaridine, artemether, artesunate, atovaquone, cycloguanil and pyrimethamine) were assessed to determine any degree of cross-resistance.

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