Rapid detection of specific gene mutations associated with isoniazid or rifampicin resistance in Mycobacterium tuberculosis clinical isolates using non-fluorescent low-density DNA microarrays
Author(s) -
Lina Marcela Aragón,
Ferrán Navarro,
Volker Heiser,
Montserrat Garrigó,
Montserrat Español,
Pere Coll
Publication year - 2006
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkl058
Subject(s) - rpob , inha , isoniazid , biology , mycobacterium tuberculosis , dna microarray , genetics , gene , microbiology and biotechnology , tuberculosis , medicine , gene expression , 16s ribosomal rna , pathology
A new, fast 'low cost and density' DNA microarray (LCD array), designed for the detection of mutations that confer isoniazid or rifampicin resistance in Mycobacterium tuberculosis isolates, has been developed and was evaluated using 46 resistant clinical isolates from Barcelona.
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