Concentration of moxifloxacin in plasma and tonsillar tissue after multiple administration in adult patients | Zendy

Silvano Esposito | Zendy; Silvaoviello | Zendy; Gioacchino D’Errico | Zendy; Gaetano Motta | Zendy; Desiderio Passàli | Zendy; Claudia Aimoni | Zendy; Stefano Pilucchi | Zendy; Stefania Fallani | Zendy; Maria Iris Cassetta | Zendy; Teresita Mazzei | Zendy; Andrea Novelli | Zendy

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Concentration of moxifloxacin in plasma and tonsillar tissue after multiple administration in adult patients

Author(s) -

Silvano Esposito,

Silvaoviello,

Gioacchino D’Errico,

Gaetano Motta,

Desiderio Passàli,

Claudia Aimoni,

Stefano Pilucchi,

Stefania Fallani,

Maria Iris Cassetta,

Teresita Mazzei,

Andrea Novelli

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl050

Subject(s) - moxifloxacin , pharmacokinetics , tonsillectomy , medicine , antibacterial agent , tonsillitis , plasma concentration , tonsil , respiratory system , antibiotics , surgery , microbiology and biotechnology , biology

The antibacterial spectrum of moxifloxacin includes all the major respiratory pathogens, and its pharmacokinetics demonstrate high peak concentrations in plasma as well as at respiratory sites. Nevertheless, tonsillar tissue concentrations have never been investigated. In this study we determined the moxifloxacin concentrations in plasma and tonsillar tissue after the administration of three doses of moxifloxacin 400 mg to adult patients with chronic or recurrent tonsillitis undergoing tonsillectomy.

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