Emergence of a 23S rRNA mutation in Mycoplasma hominis associated with a loss of the intrinsic resistance to erythromycin and azithromycin | Zendy

Sabine Pereyre | Zendy; H. Renaudin | Zendy; Alain Charron | Zendy; Cécile Bébéar | Zendy

Open Access

Emergence of a 23S rRNA mutation in Mycoplasma hominis associated with a loss of the intrinsic resistance to erythromycin and azithromycin

Author(s) -

Sabine Pereyre,

H. Renaudin,

Alain Charron,

Cécile Bébéar

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl026

Subject(s) - josamycin , 23s ribosomal rna , microbiology and biotechnology , biology , erythromycin , telithromycin , azithromycin , dalfopristin , quinupristin , macrolide antibiotics , ketolide , antibiotics , genetics , bacteria , gene , ribosome , rna , vancomycin , staphylococcus aureus

Mycoplasma hominis is intrinsically resistant to 14- and 15-membered macrolides and to the ketolide telithromycin but is susceptible to josamycin, a 16-membered macrolide, and lincosamides. The aim of our study was to investigate the in vitro development of macrolide resistance in M. hominis and to study the impact of ribosomal mutations on MICs of various macrolides and related antibiotics.

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