In vitro pharmacodynamics of rapid versus continuous infusion of amphotericin B deoxycholate against Candida species in the presence of human serum albumin | Zendy

Russell E. Lewis | Zendy; Nathan P. Wiederhold | Zendy; Randall A. Prince | Zendy; Dimitrios P. Kontoyiannis | Zendy

Open Access

In vitro pharmacodynamics of rapid versus continuous infusion of amphotericin B deoxycholate against Candida species in the presence of human serum albumin

Author(s) -

Russell E. Lewis,

Nathan P. Wiederhold,

Randall A. Prince,

Dimitrios P. Kontoyiannis

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki467

Subject(s) - pharmacodynamics , amphotericin b , pharmacology , candida albicans , in vivo , pharmacokinetics , in vitro , nephrotoxicity , amphotericin b deoxycholate , human serum albumin , chemistry , medicine , biology , microbiology and biotechnology , caspofungin , toxicity , biochemistry , antifungal

Recent open label studies have suggested that dosing amphotericin B (AMB) by continuous infusion (CI) may reduce drug-associated infusion reactions and nephrotoxicity. In vitro and in vivo pharmacodynamic (PD) data, however, do not consistently support the concept of CI dosing based on the concentration-dependent activity of this agent and in vitro studies with AMB rarely account for the drug's high degree of protein binding. Therefore, we compared the PD activity of simulated continuous versus rapid infusion strategies of AMB in killing of AMB-susceptible and -resistant Candida species using an in vitro pharmacodynamic model.

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