Third-generation cephalosporin resistance among Gram-negative bacilli causing meningitis in neurosurgical patients: significant challenges in ensuring effective antibiotic therapy | Zendy

E. O’Neill | Zendy; H. Humphreys | Zendy; Jason Phillips | Zendy; E.G. Smyth | Zendy

Open Access

Third-generation cephalosporin resistance among Gram-negative bacilli causing meningitis in neurosurgical patients: significant challenges in ensuring effective antibiotic therapy

Author(s) -

E. O’Neill,

H. Humphreys,

Jason Phillips,

E.G. Smyth

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki462

Subject(s) - cephalosporin , antibiotics , medicine , meningitis , gram , cephalosporin antibiotic , microbiology and biotechnology , bacilli , intensive care medicine , antibiotic resistance , gram negative bacteria , biology , bacteria , surgery , biochemistry , escherichia coli , gene , genetics

The treatment of meningitis caused by Gram-negative bacilli in neurosurgical patients is a major challenge because of the complexity of these patients, the emergence of antibiotic resistance in many of the causative organisms and the restricted choice of antibiotics suitable for use, owing to a failure to achieve high enough concentrations in the CSF. We reviewed the incidence, aetiology, treatment and outcome of all patients with Gram-negative bacillary meningitis (GNBM) in our centre over a 7 year period.

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