Glycosaminoglycans inhibit the antibacterial activity of LL-37 in biological fluids | Zendy

Wioletta BarańskaRybak | Zendy; Andreas Sonesson | Zendy; Roman Nowicki | Zendy; Artur Schmidtchen | Zendy

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Glycosaminoglycans inhibit the antibacterial activity of LL-37 in biological fluids

Author(s) -

Wioletta BarańskaRybak,

Andreas Sonesson,

Roman Nowicki,

Artur Schmidtchen

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki460

Subject(s) - cathelicidin , antimicrobial , antibacterial activity , chemistry , glycosaminoglycan , antibacterial agent , biological activity , antibacterial peptide , microbiology and biotechnology , bacteria , antimicrobial peptides , biochemistry , antibiotics , in vitro , biology , genetics

The antibacterial activity of antimicrobial peptides is influenced by various factors such as salt content, pH and the presence of proteins. In this study, we explored the antibacterial action of the human cathelicidin LL-37 in physiologically relevant conditions, i.e. various human wound fluids, human plasma fractions and serum.

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