Novel synthetic molecules targeting the bacterial RNA polymerase assembly | Zendy

Estelle André | Zendy; Lionel Bastide | Zendy; Sylvie MichauxCharachon | Zendy; A Gouby | Zendy; Philippe Villain-Guillot | Zendy; Jaqueline Latouche | Zendy; Aurélie Bouchet | Zendy; Maxime Gualtiéri | Zendy; JeanPaul Léonetti | Zendy

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Novel synthetic molecules targeting the bacterial RNA polymerase assembly

Author(s) -

Estelle André,

Lionel Bastide,

Sylvie MichauxCharachon,

A Gouby,

Philippe Villain-Guillot,

Jaqueline Latouche,

Aurélie Bouchet,

Maxime Gualtiéri,

JeanPaul Léonetti

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki426

Subject(s) - rna polymerase , bacterial transcription , transcription (linguistics) , bacteria , polymerase , small molecule , rna , biology , chemistry , computational biology , microbiology and biotechnology , biochemistry , enzyme , genetics , gene , linguistics , philosophy

Despite extensive functional screening of the bacterial RNA polymerase (RNAP) over the past years, very few novel inhibitors have been reported. We have, therefore, decided to screen with a radically different, non-enzymic, protein-protein interaction assay. Our target is the highly conserved RNAP-sigma interaction that is essential for transcription.

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