Differential effects of β-lactams on human IFN-γ activity | Zendy

B Brooks | Zendy; C. A. Hart | Zendy; John W. Coleman | Zendy

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Differential effects of β-lactams on human IFN-γ activity

Author(s) -

B Brooks,

C. A. Hart,

John W. Coleman

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki373

Subject(s) - aztreonam , cefotaxime , meropenem , microbiology and biotechnology , penicillin , chemistry , clavulanic acid , pharmacology , penicillin binding proteins , cephalosporin , antibiotics , medicine , biology , amoxicillin , antibiotic resistance , imipenem

To investigate whether a range of beta-lactam antibiotics conjugate to and hence reduce the activity of IFN-gamma, as has been shown for penicillin G. A selection of penicillins, cephalosporins, a monobactam (aztreonam), a beta-lactamase inhibitor (clavulanic acid), a carbapenem (meropenem) and the non-beta-lactam penicillin derivative d-penicillamine were tested for their effect on IFN-gamma activity.

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