Selection of rifampicin-resistant Staphylococcus aureus during tuberculosis therapy: concurrent bacterial eradication and acquisition of resistance | Zendy

You-ning Liu | Zendy; Junchang Cui | Zendy; Rui Wang | Zendy; Xinjing Wang | Zendy; Karl Drlica | Zendy; Xilin Zhao | Zendy

Open Access

Selection of rifampicin-resistant Staphylococcus aureus during tuberculosis therapy: concurrent bacterial eradication and acquisition of resistance

Author(s) -

You-ning Liu,

Junchang Cui,

Rui Wang,

Xinjing Wang,

Karl Drlica,

Xilin Zhao

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki364

Subject(s) - rifampicin , staphylococcus aureus , microbiology and biotechnology , tuberculosis , mycobacterium tuberculosis , antibiotics , medicine , antibiotic resistance , drug resistance , bacteria , biology , pathology , genetics

Acquired antimicrobial resistance is commonly attributed to regimens that expose bacteria to subinhibitory concentrations; consequently, eradication of susceptible cells is advocated. The mutant selection window hypothesis predicts that resistance can be acquired even when inhibitory concentrations are exceeded and susceptible bacteria are eradicated. The objective was to test that prediction clinically.

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