Interindividual variability of once-daily ritonavir boosted saquinavir pharmacokinetics in Thai and UK patients | Zendy

Reshma Autar | Zendy; Marta Boffito | Zendy; Elly A. Hassink | Zendy; Ferdinand W N M Wit | Zendy; Jintanat Ananworanich | Zendy; Umaporn Siangphoe | Zendy; Anton Pozniak | Zendy; David A. Cooper | Zendy; Praphan Phanuphak | Zendy; Joep M. A. Lange | Zendy; Kiat Ruxrungtham | Zendy; David M. Burger | Zendy

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Interindividual variability of once-daily ritonavir boosted saquinavir pharmacokinetics in Thai and UK patients

Author(s) -

Reshma Autar,

Marta Boffito,

Elly A. Hassink,

Ferdinand W N M Wit,

Jintanat Ananworanich,

Umaporn Siangphoe,

Anton Pozniak,

David A. Cooper,

Praphan Phanuphak,

Joep M. A. Lange,

Kiat Ruxrungtham,

David M. Burger

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki354

Subject(s) - saquinavir , ritonavir , cmin , pharmacokinetics , medicine , univariate analysis , cmax , area under the curve , body mass index , pharmacology , multivariate analysis , immunology , antiretroviral therapy , human immunodeficiency virus (hiv) , viral load

Differential exposure to saquinavir/ritonavir may lead to therapy failure. The objective was to identify factors that influence variability of saquinavir/ritonavir plasma concentrations.

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