Use of Pseudomonas biofilm susceptibilities to assign simulated antibiotic regimens for cystic fibrosis airway infection | Zendy

Samuel M. Moskowitz | Zendy; Jessica M. Foster | Zendy; Julia Emerson | Zendy; Ronald L. Gibson | Zendy; Jane L. Burns | Zendy

Open Access

Use of Pseudomonas biofilm susceptibilities to assign simulated antibiotic regimens for cystic fibrosis airway infection

Author(s) -

Samuel M. Moskowitz,

Jessica M. Foster,

Julia Emerson,

Ronald L. Gibson,

Jane L. Burns

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki338

Subject(s) - pseudomonas aeruginosa , cystic fibrosis , antibiotics , biofilm , medicine , regimen , microbiology and biotechnology , exacerbation , biology , bacteria , genetics

Increasing evidence indicates that Pseudomonas aeruginosa grows as a biofilm in the lungs of cystic fibrosis (CF) patients. In contrast, the bacterial inoculum used in conventional susceptibility testing is composed of planktonic cells. As a prelude to a clinical trial of biofilm susceptibility testing in CF, simulated antibiotic regimens based on either biofilm or conventional susceptibility testing of CF patient isolates were compared.

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