Open AccessCharacterization of the MacA–MacB efflux system in Neisseria gonorrhoeae
Author(s) -
Corinne E. Rouquette-Loughlin,
Jacqueline T. Balthazar,
William M. Shafer
Publication year - 2005
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dki333
Subject(s) - neisseria gonorrhoeae , efflux , escherichia coli , microbiology and biotechnology , biology , bacterial genetics , antibiotic resistance , gene , neisseria , bacteria , genetics , antibiotics
A homologue of the MacA-MacB ABC transporter of Escherichia coli, which recognizes and exports macrolides, was identified in Neisseria gonorrhoeae. This study was undertaken to determine whether gonococci could use the MacA-MacB homologue to express decreased susceptibility to macrolides.
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