Serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite chlamydia | Zendy

Mohd. Akhlakur Rahman | Zendy; Yoshinao Azuma | Zendy; Hajime Fukunaga | Zendy; Tomoyuki Murakami | Zendy; Kazurou Sugi | Zendy; Hideto Fukushi | Zendy; Koshiro Miura | Zendy; Harumi Suzuki | Zendy; Mutsunori Shirai | Zendy

Open Access

Serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite chlamydia

Author(s) -

Mohd. Akhlakur Rahman,

Yoshinao Azuma,

Hajime Fukunaga,

Tomoyuki Murakami,

Kazurou Sugi,

Hideto Fukushi,

Koshiro Miura,

Harumi Suzuki,

Mutsunori Shirai

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki331

Subject(s) - chlamydiae , biology , microbiology and biotechnology , melatonin , chlamydia , chlamydia trachomatis , intracellular parasite , chlamydophila pneumoniae , immunology , virology , immune system , endocrinology , chlamydiaceae

Chlamydiae are obligate intracellular bacteria, causing a variety of diseases, i.e. pneumonia, sexually transmitted disease, conjunctivitis and zoonosis. Tryptophan depletion by interferon-gamma (IFN-gamma) is the most important host defence system against chlamydial infection. Thus chlamydial tryptophan metabolism is thought to play key roles for IFN-gamma resistance, persistent infection and host/tissue tropisms. We tested tryptophan derivatives for activity against chlamydia-infected cells.

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