Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings | Zendy

Karl Malcolm | Zendy; A. David Woolfson | Zendy; Clare F. Toner | Zendy; Ryan J. Morrow | Zendy; Stephen D. McCullagh | Zendy

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Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings

Author(s) -

Karl Malcolm,

A. David Woolfson,

Clare F. Toner,

Ryan J. Morrow,

Stephen D. McCullagh

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki326

Subject(s) - silicone , vaginal ring , microbicide , vagina , vaginal microbicide , elastomer , human immunodeficiency virus (hiv) , reverse transcriptase inhibitor , chemistry , medicine , pharmacology , surgery , microbicides for sexually transmitted diseases , sida , population , immunology , research methodology , organic chemistry , viral disease , environmental health , family planning , health services

The feasibility of providing prolonged and controlled release of the experimental non-nucleoside reverse transcriptase inhibitor TMC120 from a silicone vaginal ring in quantities sufficient to maintain a vaginal concentration offering protection against heterosexual HIV transmission was investigated.

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