Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection | Zendy

Jane Freeman | Zendy; Simon D. Baines | Zendy; Daniela Jabés | Zendy; Mark H. Wilcox | Zendy

Open Access

Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection

Author(s) -

Jane Freeman,

Simon D. Baines,

Daniela Jabés,

Mark H. Wilcox

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki321

Subject(s) - clostridium difficile , hamster , clindamycin , vancomycin , microbiology and biotechnology , clostridium difficile toxin a , biology , antibiotics , bacteria , genetics , staphylococcus aureus

Treatment of Clostridium difficile infection (CDI) is limited primarily to either metronidazole or vancomycin. We compared vancomycin and a novel glycolipodepsipeptide, ramoplanin, in both hamster and in vitro gut models of clindamycin-induced CDI.

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