Are fluoroquinolone-susceptible isolates of Streptococcus pneumoniae really susceptible? A comparison of resistance mechanisms in Canadian isolates from 1997 and 2003 | Zendy

Kristen N. Schurek | Zendy; Heather J. Adam | Zendy; Christine G Siemens | Zendy; Chris J. Hoban | Zendy; Daryl J. Hoban | Zendy; George G. Zhanel | Zendy

Open Access

Are fluoroquinolone-susceptible isolates of Streptococcus pneumoniae really susceptible? A comparison of resistance mechanisms in Canadian isolates from 1997 and 2003

Author(s) -

Kristen N. Schurek,

Heather J. Adam,

Christine G Siemens,

Chris J. Hoban,

Daryl J. Hoban,

George G. Zhanel

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki315

Subject(s) - levofloxacin , ciprofloxacin , streptococcus pneumoniae , microbiology and biotechnology , agar dilution , ofloxacin , efflux , quinolone , biology , antibacterial agent , streptococcaceae , sparfloxacin , minimum inhibitory concentration , antibiotics , genetics

To assess the prevalence of efflux and amino acid substitutions in ParC and GyrA in Canadian clinical isolates of fluoroquinolone-susceptible Streptococcus pneumoniae with levofloxacin MICs of 1 mg/L collected before the introduction of the respiratory fluoroquinolones (1995-1997) and after 7 years of use (2003).

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