Compartmental pharmacokinetics and tissue distribution of the antifungal triazole ravuconazole following intravenous administration of its di-lysine phosphoester prodrug (BMS-379224) in rabbits | Zendy

Andreas H. Groll | Zendy; Diana Mickiene | Zendy; Vidmantas Petraitis | Zendy; Rūta Petraitienė | Zendy; Amy M. Kelaher | Zendy; Alia A. Sarafandi | Zendy; Gudrun Wuerthwein | Zendy; John Bacher | Zendy; Thomas J. Walsh | Zendy

Open Access

Compartmental pharmacokinetics and tissue distribution of the antifungal triazole ravuconazole following intravenous administration of its di-lysine phosphoester prodrug (BMS-379224) in rabbits

Author(s) -

Andreas H. Groll,

Diana Mickiene,

Vidmantas Petraitis,

Rūta Petraitienė,

Amy M. Kelaher,

Alia A. Sarafandi,

Gudrun Wuerthwein,

John Bacher,

Thomas J. Walsh

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki287

Subject(s) - pharmacokinetics , prodrug , pharmacology , cmax , chemistry , distribution (mathematics) , oral administration , medicine , mathematical analysis , mathematics

Ravuconazole is a broad-spectrum antifungal triazole in clinical development. We investigated the compartmental plasma pharmacokinetics and tissue distribution of ravuconazole following administration of its novel intravenous (i.v.) di-lysine phosphoester prodrug, BMS-379224.

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