Differential effects of three antibiotics on T helper cell cytokine expression | Zendy

Auriol C. Williams | Zendy; Helen F. Galley | Zendy; Alison M. Watt | Zendy; Nigel R. Webster | Zendy

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Differential effects of three antibiotics on T helper cell cytokine expression

Author(s) -

Auriol C. Williams,

Helen F. Galley,

Alison M. Watt,

Nigel R. Webster

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki251

Subject(s) - cytokine , antibiotics , microbiology and biotechnology , differential (mechanical device) , biology , immunology , aerospace engineering , engineering

To test whether ciprofloxacin, moxifloxacin and clarithromycin affect the expression of the T helper (Th) cell cytokines, interferon-gamma and interleukin-4. Quinolone and macrolide antibiotics are routinely used for the treatment of critically ill patients with sepsis. These antibiotics modulate some aspects of immune cell function. Alteration in the profile of Th cell cytokine expression will affect the T helper cell ratio and subsequent immune responses.

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