Treatment of experimental Escherichia coli infection with recombinant bacteriophage-derived capsule depolymerase | Zendy

Naseem Mushtaq | Zendy; Maria B. Redpath | Zendy; J. Paul Luzio | Zendy; Peter W. Taylor | Zendy

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Treatment of experimental Escherichia coli infection with recombinant bacteriophage-derived capsule depolymerase

Author(s) -

Naseem Mushtaq,

Maria B. Redpath,

J. Paul Luzio,

Peter W. Taylor

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki177

Subject(s) - microbiology and biotechnology , virulence , phagocytosis , escherichia coli , biology , infectious dose , bacterial capsule , pathogen , colonization , lethal dose , immunology , toxicology , biochemistry , virus , gene

The aim of this study was to investigate the effect of single doses of the capsule depolymerizing enzyme endosialidase E (endoE) on the course of systemic infection due to Escherichia coli K1 strains in neonatal rats. We also determined the capacity of the enzyme to increase the sensitivity of K1 strains to rat peritoneal macrophages.

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