Comparative evaluation of tigecycline and vancomycin, with and without rifampicin, in the treatment of methicillin-resistant Staphylococcus aureus experimental osteomyelitis in a rabbit model | Zendy

Liyan Yin | Zendy; Luca Lazzarini | Zendy; Fan Li | Zendy; C. Melinda Stevens | Zendy; Jason H. Calhoun | Zendy

Open Access

Comparative evaluation of tigecycline and vancomycin, with and without rifampicin, in the treatment of methicillin-resistant Staphylococcus aureus experimental osteomyelitis in a rabbit model

Author(s) -

Liyan Yin,

Luca Lazzarini,

Fan Li,

C. Melinda Stevens,

Jason H. Calhoun

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki109

Subject(s) - tigecycline , vancomycin , rifampicin , medicine , osteomyelitis , staphylococcus aureus , linezolid , antibiotics , vertebral osteomyelitis , methicillin resistant staphylococcus aureus , surgery , microbiology and biotechnology , biology , tuberculosis , bacteria , pathology , genetics

Staphylococcus aureus is the most common organism isolated in osteomyelitis. Methicillin-resistant S. aureus (MRSA) infections are particularly difficult to treat. We evaluated the efficacy of tigecycline and vancomycin with and without rifampicin in a rabbit model of MRSA osteomyelitis.

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