Induction of interleukin-1β, tumour necrosis factor-α and apoptosis in mouse organs by amphotericin B is neutralized by conjugation with arabinogalactan | Zendy

Rama Falk | Zendy; Moshe Hacham | Zendy; Abraham Nyska | Zendy; Julie F. Foley | Zendy; Abraham J. Domb | Zendy; Itzhack Polacheck | Zendy

Open Access

Induction of interleukin-1β, tumour necrosis factor-α and apoptosis in mouse organs by amphotericin B is neutralized by conjugation with arabinogalactan

Author(s) -

Rama Falk,

Moshe Hacham,

Abraham Nyska,

Julie F. Foley,

Abraham J. Domb,

Itzhack Polacheck

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki090

Subject(s) - apoptosis , tunel assay , tumor necrosis factor alpha , kidney , biology , toxicity , necrosis , amphotericin b , pharmacology , pathology , immunology , medicine , endocrinology , microbiology and biotechnology , biochemistry , antifungal , genetics

To investigate the possibilities that: (i) organ toxicity of amphotericin B-deoxycholate (AMB-DOC) is related to induction of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and apoptosis in target organs; and (ii) the reduced toxicity resulting from the conjugation of AMB with water-soluble arabinogalactan (AMB-AG), is related to modulation of these parameters.

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