Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans | Zendy

Hans-Christian Sigle | Zendy; Sascha Thewes | Zendy; M. Niewerth | Zendy; Hans Christian Körting | Zendy; Monika SchäferKorting | Zendy; Bernhard Hube | Zendy

Open Access

Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans

Author(s) -

Hans-Christian Sigle,

Sascha Thewes,

M. Niewerth,

Hans Christian Körting,

Monika SchäferKorting,

Bernhard Hube

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki089

Subject(s) - candida albicans , reactive oxygen species , mode of action , mechanism of action , antifungal drug , menadione , biology , biochemistry , corpus albicans , chemistry , microbiology and biotechnology , pharmacology , enzyme , in vitro

Ciclopirox is a topical antifungal agent of the hydroxypyridone class whose mode of action is poorly understood. In order to elucidate the mechanism of action of ciclopirox, we analysed the growth, cellular integrity, biochemical properties, viability and transcriptional profile of the polymorphic yeast Candida albicans following exposure to this antifungal agent.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research