Ceftriaxone pharmacokinetics in interleukin-10-treated murine pneumococcal pneumonia | Zendy

Erjian Wang | Zendy; Yves Bergeron | Zendy; Michel G. Bergeron | Zendy

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Ceftriaxone pharmacokinetics in interleukin-10-treated murine pneumococcal pneumonia

Author(s) -

Erjian Wang,

Yves Bergeron,

Michel G. Bergeron

Publication year - 2005

Publication title -

journal of antimicrobial chemotherapy

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dki085

Subject(s) - ceftriaxone , pneumococcal pneumonia , pharmacokinetics , medicine , pneumonia , streptococcus pneumoniae , immunology , pneumococcal infections , antibiotics , pharmacology , microbiology and biotechnology , biology

Anti-inflammatory therapy with interleukin-10 (IL-10) was previously reported to reduce pulmonary inflammation and to prevent septicaemia in murine pneumococcal pneumonia treated with ceftriaxone. In the present report, we investigated the influence of pulmonary infection and IL-10 administration on the pharmacokinetics of ceftriaxone.

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